Design of a self-unfolding delivery concept for oral administration of macromolecules

Delivering macromolecular drugs, e.g. peptides, to the systemic circulation by oral administration is challenging due their degradation in gastrointestinal tract and low transmucosal permeation. In this study, concept of an delivery device utilizing elastomeric material presented with potential increasing absorption insulin. Absorption enhancement intestine proposed as a result self-unfolding polydimethylsiloxane foil upon release from enteric coated capsules. A pH-sensitive polymer coating prevents capsule disintegration until arrival small where complete unfolding ensures close contact intestinal mucosa. Foils close-packed hexagonal compartments for optimal drug loading are produced casting against deep-etched silicon master. Complete verified vitro insulin profile final confirms protection at gastric pH. vivo performance evaluated outcome quantifiable plasma concentrations all rats receiving duodenal novel device. By taking advantage properties delivery, approach might serve inspiration further development commercially viable biocompatible devices macromolecules.